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Site ilvB
- Name: ilvB
- Type: Gene
- Synonyms
b3671 MG1655 locus tag - Mnemonic: Isoleucine-valine (requirement)
- Left End Point: 82.96
- Right End Point: 83.00
- Products:
acetolactate synthase I, valine-sensitive, ALS I AHAS I, valine-sensitive (acetohydroxy acid synthase I) - Direction: <
- Priority: 1
- 4 Alleles of This Gene
ilvB196 ilvB619 ilvB776(del)::kan ilvB792-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG10494 EcoliWiki ilvB - Comment:
- Selectable phenotype. Increased expression: a-aminobutyrate resistance; valine resistance; glycylleucine, phenylalanylleucine resistance. Valine resistance.
- References:
- Ramakrishnan, T., E.A. Adelberg 1965. Regulatory mechanisms in the biosynthesis of isoleucine and valine. II. Identification of two operator genes. J.Bacteriol. 89:654-660
- Umbarger, H.E. 1969. Regulation of the biosynthesis of the branched-chain amino acids. Curr.Topics Microbiol.Immunol. 1:57-76
- Pledger, W.J., H.E. Umbarger 1973. Isoleucine and valine metabolism in Escherichia coli. XXI. Mutations affecting derepression and valine resistance. J.Bacteriol. 113:183-194
- Davis, E.J., J.M. Blatt, E.K. Henderson, J.J. Whittaker, J.H. Jackson 1977. Valine-sensitive acetohydroxy acid synthetases in Escherichia coli K-12: unique regulation modulated by multiple genetic sites. Mol.Gen.Genet. 156:239-249
- LaCara, F., M. DeFelice 1979. Chromatographic detection of the acetohydroxy acid synthetase isoenzymes of Escherichia coli K-12. Biochem.Biophys.Res.Commun. 91:319-326
- Newman, T., M. Levinthal 1980. A new map location for the ilvB locus of Escherichia coli. Genetics 96:59-77
- Sutton, A., T. Newman, M. Francis, M. Freundlich 1981. Valine-resistant Escherichia coli K-12 strains with mutations in the ilvB operon. J.Bacteriol. 148:998-1001
- Newman, T., P. Friden, A. Sutton, M. Freundlich 1982. Cloning and expression of the ilvB gene of Escherichia coli K-12. Mol.Gen.Genet. 186:378-384
- Gollop, N., H. Tavori, Z. Barak 1982. Acetohydroxy acid synthase is a target for leucine-containing peptide toxicity in Escherichia coli. J.Bacteriol. 149:387-390
- Friden, P., T. Newman, M. Freundlich 1982. Nucleotide sequence of the ilvB promoter-regulatory region: a biosynthetic operon controlled by attenuation and cyclic AMP. Proc.Natl.Acad.Sci.USA 79:6156-6160
- Shattuck-Eidens, D.M., R.J. Kadner 1983. Molecular cloning of the uhp region and evidence for a positive activator for expression of the hexose phosphate transport system of Escherichia coli. J.Bacteriol. 155:1062-1070
- Kadner, R.J., D.M. Shattuck-Eidens 1983. Genetic control of the hexose phosphate transport system of Escherichia coli: mapping of deletion and insertion mutations in the uhp region. J.Bacteriol. 155:1052-1061
- Hauser, C.A., G.W. Hatfield 1983. Nucleotide sequence of the ilvB multivalent attenuator region of Escherichia coli K-12. Nucleic Acids Res. 11:127-139
- Wek, R.C., C.A. Hauser, G.W. Hatfield 1985. The nucleotide sequence of the ilvBN operon of Escherichia coli: sequence homologies of the acetohydroxy acid synthase isozyme. Nucleic Acids Res. 13:3995-4010
- Friden, P., J. Donegan, J. Mullen, P. Tsui, M. Freundlich, L. Eoyang, R. Weber, P.M. Silverman 1985. The ilvB locus of Escherichia coli K-12 is an operon encoding both subunits of acetohydroxy acid synthase I. Nucleic Acids Res. 13:3979-3993
- Chang, Y.Y., J.E. Cronan, S.J. Li, K. Reed, T. Vanden Boom, A.Y. Wang 1991. Locations of the lip, poxB, and ilvBN genes on the physical map of Escherichia coli. J.Bacteriol. 173:5258-4259